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Professor Se-Jung Lee's Team at Pukyong National University Developed Metformin-Based Treatment for ColitisPukyong National University (President Sang-Hoon Bae) announced that the research team led by Professor Se-Jung Lee from the Department of Smart Healthcare Convergence, Human Bio-Convergence Major, has developed an innovative metformin capsule effective in treating inflammatory bowel disease (IBD) and improving the gut microbiome. Professor Se-Jung Lee collaborated with Professor Chang-Hyung Choi from Yeungnam University, and the joint research findings were published in January in the international journal Journal of Controlled Release (IF 10.5), which specializes in chemistry and pharmacology. The research team developed an oral pH-responsive drug delivery system using microfluidic technology to encapsulate metformin, a well-known diabetes treatment, within a triple-layer hydrogel capsule. This capsule is designed to release metformin specifically in the colonic inflammation site (pH 7) while protecting the drug from degradation in the acidic gastric environment (pH 2). This approach significantly enhances the bioavailability of the drug at the target site, enabling effective treatment of inflammatory bowel disease (IBD) with lower doses. The study also revealed that metformin not only regulates the pro-inflammatory immune response mechanism in IBD animal models but also improves the diversity and richness of the gut microbiota. Professor Se-Jung Lee explained, “Patients with inflammatory colitis often face dietary restrictions, which can impair nutrient absorption, disrupt glycemic control, and increase the risk of developing Type 2 diabetes. While metformin has garnered significant attention as an exceptional diabetes treatment, its potential as a colitis treatment remains largely unexplored. Moreover, its stability and bioavailability are often compromised due to degradation by gastric acid and digestive enzymes before reaching the intestinal tract, necessitating higher doses. This encapsulation technology addresses these limitations and represents a breakthrough in drug delivery.” He further emphasized, “Our findings highlight metformin’s novel pharmacological effects and its potential as a therapeutic option for microbiome modulation and the treatment of refractory colitis through microcapsulation technology.” Additionally, Professor Lee shared his aspirations, stating, “Through the development of advanced microcapsules and microneedles, I aim to discover biopharmaceuticals, such as stem cells, peptides, and antibodies, capable of being specifically delivered to disease sites. This research will contribute to treating metabolic, chronic, and intractable diseases. I also hope to foster the next generation of talent in the field of smart healthcare.”
대외협력과 (2025-01-21)조회수 52Pukyong National University Research Team Discovers Anion Separation Phenomenon in All-Solid-State Batteries-Research by Professor Jeong Seong-cheol’s Team Published in the UK Royal Society of Chemistry Journal-Localized Anion Separation Phenomenon Causes High Ionic Conductivity Pukyong National University (President Bae Sang-hoon) announced that Professor Jeong Seong-cheol’s (Department of Physics) research team discovered a phenomenon in which monovalent and divalent ions are locally separated in the Li6PS5Cl solid electrolyte of the argyrodite structure used in all-solid-state batteries. The research team, led by Professor Jeong Seong-cheol, Postdoctoral Researcher Lee Se-ho (G-LAMP Project), and Ph.D. student Jeon Tae-gon (Department of Physics), revealed through first-principles calculations that the difference in lithium mobility due to the anion domain caused by the anion local separation discovered in the Li6-xPS5-xClBrx solid electrolyte is the cause of the high ion conductivity in the Li6PS5Cl series solid electrolytes. Solid electrolytes based on the argyrodite structure have excellent ion conductivity, good cost-effectiveness of raw materials, and ease of synthesis, leading to active research in this field. Professor Jung’s team found that in this study, lithium ions are more concentrated in the S2- divalent anion region than in the Cl- and Br- monovalent anion regions, leading to the effective stabilization of the argyrodite structure. Additionally, lithium ions in the divalent anion region showed low mobility due to their strong binding with the anions, while lithium ions in the monovalent anion region exhibited higher mobility due to weaker binding with the anions. Through this, they identified that the lithium diffusion mechanism in argyrodite solid electrolytes relies on the anion regions. Professor Jung Seong-cheol stated, “This study reveals that the well-known disordered arrangement of anions in Li6PS5Cl-based argyrodite solid electrolytes is actually related to the local separation of anions, providing a new perspective for understanding the high conductivity of argyrodite solid electrolytes.” Meanwhile, this research was conducted with support from the Ministry of Education’s G-LAMP project and was recently published in the prestigious international journal
Pukyong National University Professor Kim Young-mok’s Research Team Publishes Paper in Top Environmental Engineering and Safety Journal-
Pukyong National University Professor Kwon Hyuk-jin’s Research Team Develops Low-power Driven Printed Flexible Transistor Electronic DevicesPukyong National University (President Bae Sang-hoon) announced that Professor Kwon Hyuk-jin’s research team (Major of Industrial Chemistry) has developed polyimide-based gate dielectric technology, which is being recognized as a key material for next-generation flexible electronic devices. Professor Kwon Hyuk-jin, along with Professor Lim Bo-gyu, Chungbuk National University (Major of Industrial Chemistry), Professor Kim Se-hyun, Konkuk University (Department of Chemical Engineering), and Professor Lee Seung-woo, Yeungnam University (Department of Chemical Engineering), and the collaborative research team, published their findings in the materials science international journal
‘COVID-19 Strengthens Internet Social Networks Among Black College Students in the U.S.’- Research Findings by Professor Lee Eun of Pukyong National University A study has found that during the COVID-19 pandemic, the reciprocity of internet social networks among Black college students in the U.S., who expressed feelings of depression, has been strengthened. Professor Lee Eun (Department of Scientific Computing) at Pukyong National University has published the paper titled ‘Internet-Based Social Connections of Black American College Students in Pre-COVID-19 and Peri-COVID-19 Pandemic Periods: Network Analysis’ as the lead author in the latest issue of the international journal
Pukyong National University, ‘Attention’ to Research on Antibiofilm Applications of Marine-Derived Substances-Professor Kim Young-mok’s Research Team … Published in the Prestigious Journal , a Sister Journal of
First Discovery of a New Species of Ttibyeolbaragi (Limnichthys koreanus) in South Korea-Research Team at Pukyong National University Reports First Subtropical Species of Creediidae in South KoreaResearcher Lee Yu-jin from Pukyong National University (Ph.D. Candidate in Marine Biology) published a new species, ‘Ttibyeolbaragi (Limnichthys koreanus),’ in the October issue of the prestigious international journal in zoology, . The paper is titled ‘Limnichthys koreanus, a new species of creediid fish (Teleostei, Acropomatiformes, Creediidae) from Korea’ (Advisor: Professor Kim Jin-goo). The newly reported species, Limnichthys koreanus, is a small fish measuring less than 5 cm, collected by Professor Kim Jin-goo while skin diving in Moseulpo, Jeju Island. This is also the first time that a subtropical species of the Creediidae fish has been reported in South Korea. The Creediidae family has never had a single species reported in South Korea, making it a taxon with no biological information available. In a study where researcher Lee Yu-jin raised Limnichthys koreanus in a laboratory tank for three months, it was found that the fish has a unique behavior of hiding in gravel and sand, then leaping at an incredible speed to intercept food when small crustaceans, such as water striders, approach, before returning to its original position. Additionally, its heart rate was measured at 190 to 240 beats per minute, indicating that it can move remarkably fast despite being a small fish. The research team went through some ups and downs almost losing the species they had just discovered. Professor Kim Jin-goo initially collected this species and placed it in a collection jar with other specimens, but when he checked outside the water, he could not find it. After returning to her accommodation, researcher Lee Yu-jin shook the collection jar to examine the specimens, during which a Istigobius campbelli in the jar regurgitated the undigested Limnichthys koreanus, allowing them to confirm the species again, leading to the announcement of the new species. Professor Kim Jin-goo stated, “Limnichthys koreanus is a small fish species that lives hidden in the gravel of the shallow intertidal zone at a depth of 1-2 meters in Moseulpo, Jeju Island, and due to its unique characteristic of being found only in Jeju, there is a need for follow-up research for species conservation as well as various efforts for habitat protection in the future.” Professor Kim Jin-goo has operated the marine fish resource donation and registration preservation agency under the Ministry of Oceans and Fisheries for 11 years, and with the budget support from the National Marine Biodiversity Institute, he has achieved research results reporting the new species of Limnichthys koreanus, dedicating himself to the assetization of marine fish resources. To date, he has successfully secured over 800 specimens of native fish species, and the Limnichthys koreanus specimens have been transferred to the National Marine Biodiversity Institute for continued research use.
대외협력과 (2024-10-25)조회수 538Pukyong National University·Tech University of Korea·Sungkyunkwan University, Develop New Cancer Treatment Technology Using ‘Nano-Bubbles’-Nano-Bubbles Responsive to Ultrasound… Destroying Cancer Cell Nuclei to Treat Metastatic CancerProfessor Eom Woo-ram from the Department of Bioengineering at Pukyong National University, Professor Yoo Dong-gil from Tech University of Korea, and Professor Park Jae-hyung from Sungkyunkwan University have successfully developed a new type of mechanical cell death method(caviptosis) that can dramatically enhance the efficacy of cancer immunotherapy, marking the first development of its kind in the world. Cancer immunotherapy is a method of treating cancer by utilizing the body's immune function, and it is gaining attention for its lower side effects and superior treatment effects compared to traditional chemotherapy. In particular, immune checkpoint inhibitors, which are a representative method of immunotherapy capable of normalizing immune responses disrupted by cancer cells, are being actively applied clinically to treat various types of cancer. However, recent studies have shown that when there is a deficiency in the number of cytotoxic T cells present in the tumor microenvironment, the effectiveness of immune checkpoint inhibitor therapy significantly decreases. Consequently, there has been a continuous demand for new technologies that can attract external immune cells to the tumor site to enhance the efficacy of cancer immunotherapy and expand treatment benefits to a larger patient population. Professor Eom Woo-ram's research team focused on the role of eosinophils, a type of white blood cell. Although eosinophils are generally known to have a negative impact on cancer treatment, they can be stimulated by interleukin-33 (IL-33), which resides inside the cell nucleus, to attract immune cells into the tumor and exhibit strong anti-cancer effects. However, IL-33 is tightly bound within the cell nucleus, making treatment options utilizing eosinophils and IL-33 extremely limited. Professor Eom Woo-ram's research team successfully developed a mechanical cell death method (cavitopsis) that can rupture cells when exposed to ultrasound by utilizing nano-sized bubbles capable of penetrating into the cells. The nano-explosive agent made from nano-bubbles responsive to ultrasound ruptures the nuclei of cancer cells, releasing IL-33, which is hardly released in its natural state, into the extracellular space. This IL-33 stimulates eosinophils to attract immune cells into the tumor, elucidating its anti-cancer effect. The research team validated the therapeutic efficacy of the nano-explosive agent in a real lung metastatic cancer mouse model, confirming a dramatic enhancement in the anti-cancer efficacy of existing immune checkpoint inhibitors. The principal investigator, Professor Eom Woo-ram, stated, “Currently, cancer immunotherapy is very expensive, costing millions of won, and has limitations as it is effective only for a subset of patients. However, I expect that this research will dramatically enhance the therapeutic efficacy of cancer immunotherapy, increasing the potential for treating metastatic cancers that have been difficult to treat with existing therapies.” The research team conducted this study with the support of the National Research Foundation of Korea’s Individual Basic Research and National New Drug Development projects. The research results were published in the international journal
Pukyong National University Faculty Startup Company, Reveals the Sleep Improvement Effect of Lime Peel for the First Time- Nutraight Co., Ltd. Publishes Paper in an International Journal and Pursues Export of Health Functional Foods Pukyong National University faculty startup company Nutraight (CEO Cho Seung-mok, Professor of Food Engineering) has revealed the sleep improvement effects and mechanisms of action from the peel of lime, a type of citrus fruit for the first time. Nutraight Co., Ltd.'s research team, in collaboration with Dr. Lee Jae-gwang's research team at the Korea Food Research Institute and Professor Jang H. Youn's research team at the University of Southern California's School of Medicine, scientifically elucidated the sleep effects and mechanisms of action of lime peel. The research team, with support from the TIPS program of the Ministry of SMEs and Startups, explored globally recognized raw materials to develop high-quality sleep functional ingredients that can enhance global competitiveness. The study found that lime peel extract showed significant reductions in sleep onset time and increases in total sleep time in animal tests. In particular, it was confirmed that lime peel extract has the ability to increase deep sleep and improve sleep quality. The sleep effects of lime peel extract are attributed to the flavonoid compounds abundantly found in lime peel, which activate GABA receptors like the inhibitory neurotransmitter GABA in the central nervous system, and this mechanism of action has been scientifically proven. The research team recently published a paper containing these research results in the prestigious international journal
Revealed the Correlation Between Excessive Alcohol Consumption in Adolescents and 'Risky Sexual Behaviors'-Research Results from Professors Heo Won-bin and Oh Young-sam at Pukyong National UniversityResearch has found that as adolescents' alcohol consumption increases, the likelihood of engaging in 'Risky Sexual Behaviors' also rises. Professors Heo Won-bin and Oh Young-sam from the Department of Social Welfare at Pukyong National University presented research findings that clarify the correlation between alcohol consumption and risky sex behavior among Korean adolescents who have had sexual experiences with the opposite sex. Risky sex behaviors refer to sexual activities that do not involve contraception, such as the use of condoms. The research team conducted the study using statistical data from the 16th(2020) Youth Health Behavior Survey, focusing on 54,948 participants(from 7th grade to 12th grade). Among these, they examined 2,487 adolescents who had sexual experiences with the opposite sex, comparing 547 adolescents who consumed alcohol with 547 who did not. The research team analyzed the statistical data using methods such as Propensity Score Matching (PSM) and Multiple Logistic Regression Analyses. The results showed that the presence or absence of alcohol consumption itself was not related to risky sexual behaviors. However, when analyzing only the group that consumed alcohol (547 participants), it was found that as alcohol consumption increased, the likelihood of engaging in risky sex behaviors, meaning having sexual intercourse without contraception, also increased. In particular, when analyzing gender differences, it was revealed that the likelihood of engaging in risky sex behavior increased with alcohol consumption only among female adolescents, while no such association was observed in male adolescents. Professor Oh Young-sam stated, “To ensure proper sexual behavior and awareness among adolescents, it is necessary to establish various educational programs and protective measures regarding sex in homes, schools, and communities.” The research findings are published in the paper titled ‘The Relationships Between Alcohol Drinking and Risky Sexual Behavior Among Korean Adolescents: Focusing on Heterosexual Adolescents’ in the latest issue of the international journal
Pukyong National University · Korea Institute of Materials Science · GIST, Develop Technology to Enhance the Lifespan of Hydrogen Fuel Cells- Development of New Carbon Material Additives for Electrodes… Significantly Improved the Durability of Polymer Electrolyte Membrane Fuel CellsProfessor Seo Min-ho from the Department of Nanotechnology Engineering at Pukyong National University, Dr. Choi Seung-mok from the Korea Institute of Materials Science, and Professor Eom Kwang-seop from the Gwangju Institute of Science and Technology (GIST) research team have successfully enhanced the durability of a commercial-grade polymer electrolyte fuel cell system by utilizing a newly developed carbon material, which was created for the first time globally, as an additive in the electrode manufacturing process. Polymer electrolyte membrane fuel cells, which are gaining attention as environmentally friendly and high-efficiency batteries, generate electricity by using hydrogen as fuel through a hydrogen oxidation reaction, emitting only water as a reaction product. However, in conventional polymer electrolyte fuel cell systems, the start-up and shut-down processes generate high voltages above 1.4V, which accelerates carbon corrosion in the catalyst layer. This leads to the collapse of the catalyst layer and the phenomenon of water accumulation inside the electrodes due to the water produced during the oxygen reduction reaction (water flooding), which caused a problem with significant reduction in durability. Professor Seo Min-ho's research team effectively improved the decline in durability of fuel cells caused by carbon corrosion by utilizing a new carbon material with high carbon corrosion resistance as an additive in the electrodes. The fluorine-doped graphene nanoribbons and carbon nanotube composite (F-GNR@CNT) used in this study were developed to overcome the carbon corrosion vulnerability of existing graphene nanoribbon oxides. Existing graphene nanoribbon oxides become enriched with oxygen functional groups due to strong chemical oxidation during the synthesis process, resulting in significant defects and instability at the boundary regions, making them highly susceptible to electrochemical carbon corrosion during fuel cell operation. Professor Seo Min-ho’s research team synthesized a carbon nanotube composite with high corrosion resistance by controlling the oxidation level and formed stable carbon-fluorine bonds through a heat treatment process for fluorine doping. Professor Seo Min-ho’s research team developed an electrode manufacturing technology that optimizes the process of adding a minimal amount of the F-GNR@CNT composite in collaboration with Dr. Choi Seung-Mok from the Korea Institute of Materials Science and Dr. Choi Young-Woo from the Korea Institute of Energy Technology and manufactured the electrodes. In collaboration with Professor Eom Kwang-Seob’s research team from GIST, the durability of accelerated electrochemical carbon corrosion of these electrodes was evaluated, and the results indicated that the degradation rate in the mass transport region of the existing catalyst layer electrode was approximately 85%, while the electrode with the added new carbon material exhibited a degradation rate of about 40%, confirming a very high resistance to electrochemical carbon corrosion. The principal investigator, Professor Seo Min-ho, stated that “the fluorine-doped graphene nanoribbon and carbon nanotube composite, proven through a combination of experiments and computational science, will be an important strategy for efficiently and easily developing high-durability hydrogen fuel cells when used as an additive in electrodes. This research achievement was carried out with support from the Pukyong National University’s Young Researcher Challenge Research, the Korea Energy Technology Evaluation Institute, the Korea Industrial Technology Planning and Evaluation Institute, and the fundamental projects of the Korea Institute of Materials Science. The research results were published in the international journal
Research on Future Wireless Optical Communication Using Ultraviolet Light Gained International Attention-Professor Jeong Yeon-ho’s Team at Pukyong National University Published Paper in the Top-ranked International Journal in the JCRResearch on developing new wireless optical communication technology for the future using ultraviolet light is gaining international attention. The paper titled ‘A Comprehensive Survey on Optical Scattering Communications: Current Research, New Trends, and Future Vision’ by Professor Jeong Yeon-ho’s research team from Pukyong National University (Major of Information and Communications Engineering) was published in the latest issue (Volume 26, Issue 2) of the international journal
Dispensing System Developed by Pukyong National University Professor’s Team Published in a Top Global Journal- Professor Lim Do-jin’s Research Team … Published a Paper in
Professor Lim Do-jin's Research Team at Pukyong National University Published Cover Paper in International Journal- Development of a New Technology for Droplet 3D Cell Culture in Oil… Published in the International Journal 《Small Methods》The paper by Professor Lim Do-jin’s research team from Pukyong National University (Department of Chemical Engineering) was published as the cover article in the international journal 《Small Methods (IF 10.7)》. The title of the paper published as the cover article in the latest issue of this journal is ‘3D Cell Culture Method in Channel-Free Water-in-Oil Droplets.’ In this paper, Professor Lim Do-jin’s research team developed and presented a novel droplet-based 3D cell culture technology in oil that does not use channels (passages) for the cultivation of organoids, which are models of artificial organs. Organoids are artificially created organ models that are gaining attention as a new preclinical model capable of replacing animal experiments, often referred to as the ’game changer of regenerative medicine‘ in the future. However, due to the size limitations of 3D cell cultures determined by the size of the culture system, there is a limitation in organoid cultivation that necessitates a cumbersome and complex process of sequentially changing the culture system. To address this issue, the research team achieved the formation of various sizes of 3D cell cultures through a simple system configuration using a novel droplet (a very small, round drop) 3D cell culture technology that does not utilize channels. The first author of this research paper, Ph.D. student Bae Seo-jun, systematically analyzed over 10,000 spheroid images and discovered that the size of spheroids formed can be determined by controlling the droplet size. He stated, “The droplet-based 3D cell culture technology in oil that does not use channels, combined with digital microfluidics that excels in droplet manipulation, is expected to aid in the development of automated organoid culture systems.” Professor Lim Do-jin’s research team conducted this study with the support of the Mid-Career Researcher Support Project from the National Research Foundation of Korea.
대외협력과 (2024-10-25)조회수 301Professor Lim Hae-kyun’s Team at Pukyong National University Developed Ultrasonic Dual Diagnosis System for Water Supply Pipes through Global Collaboration- Simultaneous Measurement of Water Supply Pipe Corrosion and Water Quality... Published in the Nature Sister Journal
Research on tripling the performance of organic photodetectors published in a Nature sister journal- prof. Park Song-Yi from PKNU investigated characteristics of organic semiconductors for high-performance organic photodetectors△ Image related to professor Park Song-Yi's research. Schematic of the organic semiconductor molecular structure, the organic photodetector device structure, and the photoelectric conversion process used in the research (top), simulation results of energy level separation in Cl6-SubPc thin films (bottom left), and photodetection capability results based on Cl6-SubPc thickness (bottom right). New research results have shown that the performance of organic photodetectors, which are emerging as next-generation image sensors, can be improved by more than three times compared to existing technologies, attracting significant attention. Professor Park Song-Yi from the department of physics at Korea Pukyong National University recently published research findings in the international journal